27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology-Reference-Cited by-同舟云学术

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

Published:2013-11-29 Issue:6162 Volume:342 Page:1094-1098
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nelson Erik R.¹,Wardell Suzanne E.¹,Jasper Jeff S.¹,Park Sunghee¹,Suchindran Sunil²,Howe Matthew K.¹,Carver Nicole J.¹,Pillai Ruchita V.¹,Sullivan Patrick M.³,Sondhi Varun⁴,Umetani Michihisa⁴,Geradts Joseph⁵,McDonnell Donald P.¹

Affiliation:

1. Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

2. Duke Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA.

3. Division of Geriatrics, Department of Medicine, Duke University School of Medicine, Durham, NC 27710, USA.

4. Departments of Pediatrics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

5. Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA.

Abstract

Cholesterol and Cancer Obesity and high cholesterol levels are associated with an increased risk of breast cancer in post-menopausal women. Nelson et al. (p. 1094 ) found that a specific metabolite of cholesterol, 27-hydroxycholesterol (27HC), promoted tumor growth and metastasis in mouse models of mammary cancer by serving as a partial agonist for the estrogen receptor and the liver X receptor. The most aggressive human breast cancers were found to express the highest level of the enzyme that converts cholesterol to 27HC, suggesting that 27HC produced within tumors (in addition to circulating 27HC) may contribute to tumorigenesis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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