Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury-Reference-Cited by-同舟云学术

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

Published:2012-06 Issue:6085 Volume:336 Page:1182-1185
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

van den Brand Rubia¹²,Heutschi Janine¹²,Barraud Quentin¹²,DiGiovanna Jack³⁴,Bartholdi Kay¹²,Huerlimann Michèle¹,Friedli Lucia¹²,Vollenweider Isabel¹²,Moraud Eduardo Martin³⁴,Duis Simone¹²,Dominici Nadia¹²,Micera Silvestro³⁴,Musienko Pavel¹²,Courtine Grégoire¹²

Affiliation:

1. Neurology Department, University of Zurich, CH-8008 Zurich, Switzerland.

2. Center for Neuroprosthetics and Brain Mind Institute, School of Life Sciences, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland.

3. Center for Neuroprosthetics, School of Engineering, Swiss Federal Institute of Technology (EPFL), CH-1015 Lausanne, Switzerland.

4. Automatic Control Laboratory, Swiss Federal Institute of Technology (ETH), CH-8092 Zurich, Switzerland.

Abstract

Regaining Limb Movement Despite many years of intensive research, there is still an urgent need for novel treatments to help patients restore motor function after spinal cord injuries. van den Brand et al. (p. 1182 ) produced left and right hemisections at different levels of the rat thoracic spinal cord to cause complete hind limb paralysis mimicking the situation in humans with spinal cord injury. Systemic application of pharmacological agents, combined with a multisystem rehabilitation program including a robotic postural neuroprosthesis, restored voluntary movements of both hind limbs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. Recovery of locomotion after chronic spinalization in the adult cat

2. Effects of training on the recovery of full-weight-bearing stepping in the adult spinal cat

3. Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries

4. Laufband Therapy Based on‘Rules of Spinal Locomotion’is Effective in Spinal Cord Injured Persons

5. Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study

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