IP 3 Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism-Reference-Cited by-同舟云学术

IP 3 Receptor Types 2 and 3 Mediate Exocrine Secretion Underlying Energy Metabolism

Published:2005-09-30 Issue:5744 Volume:309 Page:2232-2234
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Futatsugi Akira¹²³⁴⁵,Nakamura Takeshi¹²³⁴⁵,Yamada Maki K.¹²³⁴⁵,Ebisui Etsuko¹²³⁴⁵,Nakamura Kyoko¹²³⁴⁵,Uchida Keiko¹²³⁴⁵,Kitaguchi Tetsuya¹²³⁴⁵,Takahashi-Iwanaga Hiromi¹²³⁴⁵,Noda Tetsuo¹²³⁴⁵,Aruga Jun¹²³⁴⁵,Mikoshiba Katsuhiko¹²³⁴⁵

Affiliation:

1. Calcium Oscillation, International Cooperative Research Project, Japan Science and Technology Agency, Tokyo 108-0071, Japan.

2. Laboratory for Developmental Neurobiology, Brain Development Research Group, Brain Science Institute, RIKEN, Saitama 351-0198, Japan.

3. Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan.

4. Department of Anatomy, School of Medicine, Hokkaido University, Sapporo 060-8638, Japan.

5. Department of Cell Biology, Japanese Foundation for Cancer Research, Cancer Institute, Tokyo 170-8455, Japan.

Abstract

Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP 3 R2 and IP 3 R3) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP 3 R2 and IP 3 R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a lack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP 3 R2 and IP 3 R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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