C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response-Reference-Cited by-同舟云学术

C57BL/6N Mutation in Cytoplasmic FMRP interacting protein 2 Regulates Cocaine Response

Published:2013-12-20 Issue:6165 Volume:342 Page:1508-1512
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kumar Vivek¹²,Kim Kyungin¹,Joseph Chryshanthi¹,Kourrich Saïd³,Yoo Seung-Hee¹,Huang Hung Chung¹,Vitaterna Martha H.⁴,Pardo-Manuel de Villena Fernando⁵,Churchill Gary⁶,Bonci Antonello³⁷,Takahashi Joseph S.¹²

Affiliation:

1. Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390–9111, USA.

2. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390–9111, USA.

3. Intramural Research Program, National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD 21224, USA.

4. Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA.

5. Department of Genetics, University of North Carolina–Chapel Hill, Chapel Hill, NC 27599, USA.

6. Jackson Laboratory, Bar Harbor, ME 04609, USA.

7. Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Abstract

Not All Mice Are Equal Different laboratories often use different strains of inbred animals, but one cannot make behavioral comparisons and assume that their reaction to interventions will necessarily be similar. Kumar et al. (p. 1508 ) have detected differences in cocaine response between the widely used C57BL/6N and C57BL/6J mouse strains and used quantitative trait locus analysis to identify a mutation in an inducible gene, Cyfip , that interacts with the Fragile X protein (FMRP) to regulate sensitivity and sensitization to cocaine through regulation of neuronal connectivity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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