An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2-Reference-Cited by-同舟云学术

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

Published:2013-01-25 Issue:6118 Volume:339 Page:464-467
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Korobova Farida¹,Ramabhadran Vinay²,Higgs Henry N.¹

Affiliation:

1. Department of Biochemistry, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.

2. Howard Hughes Medical Institute, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA.

Abstract

Masterminding Mitochondrial Fission Mitochondria are highly dynamic and undergo fusion and fission and they move in cells. Defects in mitochondrial dynamics are implicated in many neurodegenerative diseases. Recent findings have suggested that mitochondrial fission occurs preferentially at endoplasmic reticulum (ER) contact sites, with ER circumscribing mitochondria and possibly promoting the constriction of mitochondria during fission. Korobova et al. (p. 464 ) now suggest that an ER-localized formin, INF2, is required for mitochondrial fission and that INF2-mediated actin polymerization facilitates mitochondrial constriction.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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