Innate lymphoid cells regulate intestinal epithelial cell glycosylation-Reference-Cited by-同舟云学术

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Published:2014-09-12 Issue:6202 Volume:345 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Goto Yoshiyuki¹²³,Obata Takashi¹³,Kunisawa Jun¹⁴⁵,Sato Shintaro¹²,Ivanov Ivaylo I.⁶,Lamichhane Aayam¹,Takeyama Natsumi¹⁷,Kamioka Mariko¹,Sakamoto Mitsuo³,Matsuki Takahiro⁸,Setoyama Hiromi⁸,Imaoka Akemi⁸,Uematsu Satoshi⁹¹⁰,Akira Shizuo¹¹,Domino Steven E.¹²,Kulig Paulina¹³,Becher Burkhard¹³,Renauld Jean-Christophe¹⁴,Sasakawa Chihiro⁷¹⁵¹⁶,Umesaki Yoshinori⁸,Benno Yoshimi¹⁷,Kiyono Hiroshi¹²⁵

Affiliation:

1. Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

2. Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan.

3. Microbe Division/Japan Collection of Microorganisms, RIKEN BioResource Center, Tsukuba 305-0074, Japan.

4. Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka 567-0085, Japan.

5. Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

6. Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA.

7. Nippon Institute for Biological Science, Tokyo 198-0024, Japan.

8. Yakult Central Institute, Tokyo 186-8650, Japan.

9. Division of Innate Immune Regulation, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

10. Department of Mucosal Immunology, School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba, 260-8670, Japan.

11. Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan.

12. Department of Obstetrics and Gynecology, Cellular and Molecular Biology Program, University of Michigan Medical Center, Ann Arbor, MI 48109-5617, USA.

13. Institute of Experimental Immunology, University of Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland.

14. Ludwig Institute for Cancer Research and Université Catholique de Louvain, Brussels B-1200, Belgium.

15. Division of Bacterial Infection, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

16. Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan.

17. Benno Laboratory, Innovation Center, RIKEN, Wako, Saitama 351-0198, Japan.

Abstract

Immune cells and bugs make a sugary coat Epithelial cells line the intestinal tract and help to keep the peace between our immune system and our trillions of gut microbes. Such peacekeeping requires glycosylated proteins (proteins with attached carbohydrate chains) present on the epithelial cell surface, but how glycosylation occurs is unclear. Goto et al. find that fucosylation (a type of glycosylation) of gut epithelial cells in mice requires gut microbes (see the Perspective by Hooper). This process also requires innate lymphoid cells there, which produce the cytokines interleukin-22 and lymphotoxin, presumably in response to microbial signals. These cytokines signal epithelial cells to add fucose to membrane proteins, which allows the détente between microbes and immune cells to continue. Science , this issue 10.1126/science.1254009 ; see also p. 1248

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference56 articles.

1. Intestinal epithelial cells as mediators of the commensal–host immune crosstalk

2. Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

3. RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

4. Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

5. The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

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