Affiliation:
1. Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA.
Abstract
Leukocytes extravasate from the blood into inflammatory sites through complementary ligand interactions between leukocytes and endothelial cells. Activation of T cells increases their binding to hyaluronate (HA) and enables CD44-mediated primary adhesion (rolling). This rolling could be induced in vivo in murine V
β
8
+
T cells in response to specific superantigen stimulation; it was initially found in lymph nodes, then in peripheral blood, and finally within the peritoneum, the original inflamed site. The migration of V
β
8
+
cells into the peritoneal cavity was dependent on CD44 and HA, as shown by inhibition studies. Thus, CD44-HA interactions can target lymphocytes to specific extralymphoid effector sites.
Publisher
American Association for the Advancement of Science (AAAS)
Reference38 articles.
1. Mackay C. R., Immunol. Today 12, 189 (1991).
2. Koster F. T., McGregor D. D., J. Exp. Med. 133, 864 (1971).
3. Guy G. D., Griscelli C., Vassalli P., ibid. 148, 1661 (1978).
4. Issekutz T. B., J. Immunol. 147, 4178 (1991).
5. Lymphocyte Homing and Homeostasis
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