A Low Genomic Number of Recessive Lethals in Natural Populations of Bluefin Killifish and Zebrafish-Reference-Cited by-同舟云学术

A Low Genomic Number of Recessive Lethals in Natural Populations of Bluefin Killifish and Zebrafish

Published:2002-06-28 Issue:5577 Volume:296 Page:2398-2401
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

McCune Amy R.¹,Fuller Rebecca C.²,Aquilina Allisan A.¹,Dawley Robert M.³,Fadool James M.²,Houle David²,Travis Joseph²,Kondrashov Alexey S.⁴

Affiliation:

1. Department of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY 14853, USA.

2. Department of Biological Sciences, Florida State University, Tallahassee, FL 32306–4340, USA.

3. Department of Biology, Ursinus College, Main Street, Collegeville, PA 19426–1000, USA.

4. National Center for Biotechnology Information, National Institutes of Health, 45 Center Drive, Bethesda, MD 20892–6510, USA.

Abstract

Despite the importance of selection against deleterious mutations in natural populations, reliable estimates of the genomic numbers of mutant alleles in wild populations are scarce. We found that, in wild-caught bluefin killifish Lucania goodei (Fundulidae) and wild-caught zebrafish Danio rerio (Cyprinidae), the average numbers of recessive lethal alleles per individual are 1.9 (95% confidence limits 1.3 to 2.6) and 1.4 (95% confidence limits 1.0 to 2.0), respectively. These results, together with data on several Drosophila species and on Xenopus laevis , show that phylogenetically distant animals with different genome sizes and numbers of genes carry similar numbers of lethal mutations.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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