Rapid Folding of DNA into Nanoscale Shapes at Constant Temperature

Author:

Sobczak Jean-Philippe J.1,Martin Thomas G.1,Gerling Thomas1,Dietz Hendrik1

Affiliation:

1. Physics Department, Walter Schottky Institute, Technische Universität München, Am Coulombwall 4a, 85748 Garching near Munich, Germany.

Abstract

Speeding Up Nanoscale DNA Assembly An impressive array of three-dimensional (3D) nanoscale objects has been assembled by folding a long, single-stranded DNA scaffold by binding of short DNA staples. However, these processes tend to be slow and inefficient. Sobczak et al. (p. 1458 ) examined the folding process with an intercalating fluorescence dye to measure the formation of double-stranded DNA in folding processes or single-stranded DNA in unfolding. Reaction conditions were identified that sped up folding by orders of magnitude and increased yields of the 3D nanoscale objects to nearly 100%.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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