Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness-Reference-Cited by-同舟云学术

Characterization of an Avian Influenza A (H5N1) Virus Isolated from a Child with a Fatal Respiratory Illness

Published:1998-01-16 Issue:5349 Volume:279 Page:393-396
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Subbarao Kanta¹²³,Klimov Alexander¹²³,Katz Jacqueline¹²³,Regnery Helen¹²³,Lim Wilina¹²³,Hall Henrietta¹²³,Perdue Michael¹²³,Swayne David¹²³,Bender Catherine¹²³,Huang Jing¹²³,Hemphill Mark¹²³,Rowe Thomas¹²³,Shaw Michael¹²³,Xu Xiyan¹²³,Fukuda Keiji¹²³,Cox Nancy¹²³

Affiliation:

1. K. Subbarao, A. Klimov, J. Katz, H. Regnery, H. Hall, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, N. Cox, Influenza Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

2. W. Lim, Government Virus Unit, Queen Mary Hospital, Hong Kong, China.

3. M. Perdue and D. Swayne, Southeast Poultry Research Laboratory, Agriculture Research Service, U.S. Department of Agriculture, Athens, GA 30605, USA.

Abstract

An avian H5N1 influenza A virus (A/Hong Kong/156/97) was isolated from a tracheal aspirate obtained from a 3-year-old child in Hong Kong with a fatal illness consistent with influenza. Serologic analysis indicated the presence of an H5 hemagglutinin. All eight RNA segments were derived from an avian influenza A virus. The hemagglutinin contained multiple basic amino acids adjacent to the cleavage site, a feature characteristic of highly pathogenic avian influenza A viruses. The virus caused 87.5 to 100 percent mortality in experimentally inoculated White Plymouth Rock and White Leghorn chickens. These results may have implications for global influenza surveillance and planning for pandemic influenza.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference23 articles.

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