Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant-Reference-Cited by-同舟云学术

Genetic Restriction of AIDS Pathogenesis by an SDF-1 Chemokine Gene Variant

Published:1998-01-16 Issue:5349 Volume:279 Page:389-393
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Winkler Cheryl¹²³⁴⁵,Modi William¹²³⁴⁵,Smith Michael W.¹²³⁴⁵,Nelson George W.¹²³⁴⁵,Wu Xueyun¹²³⁴⁵,Carrington Mary¹²³⁴⁵,Dean Michael¹²³⁴⁵,Honjo Tasaku¹²³⁴⁵,Tashiro Kai¹²³⁴⁵,Yabe D.¹²³⁴⁵,Buchbinder Susan¹²³⁴⁵,Vittinghoff Eric¹²³⁴⁵,Goedert James J.¹²³⁴⁵,O'Brien Thomas R.¹²³⁴⁵,Jacobson Lisa P.¹²³⁴⁵,Detels Roger¹²³⁴⁵,Donfield Sharyne¹²³⁴⁵,Willoughby Anne¹²³⁴⁵,Gomperts Edward¹²³⁴⁵,Vlahov David¹²³⁴⁵,Phair John¹²³⁴⁵,O'Brien Stephen J.¹²³⁴⁵, , , , ,

Affiliation:

1. C. Winkler, W. Modi, M. W. Smith, G. W. Nelson, X. Wu, M. Carrington, Science Applications International Corporation (SAIC), National Cancer Institute, Frederick, MD 21702, USA.

2. M. Dean and S. J. O'Brien, Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA.

3. T. Honjo and D. Yabe, Department of Medical Chemistry, Kyoto University, Kyoto, Japan.

4. K. Tashiro, Center for Molecular Biology and Genetics, Kyoto University, Kyoto, Japan.

5. S. Buchbinder and E. Vittinghoff, AIDS Office, Department of Public Health, 25 Van Ness Avenue, Suite 500, San Francisco, CA 94102, USA.

Abstract

Stromal-derived factor (SDF-1) is the principal ligand for CXCR4, a coreceptor with CD4 for T lymphocyte cell line–tropic human immunodeficiency virus–type 1 (HIV-1). A common polymorphism, SDF1-3′A , was identified in an evolutionarily conserved segment of the 3′ untranslated region of the SDF-1 structural gene transcript. In the homozygous state, SDF1-3′A / 3′A delays the onset of acquired immunodeficiency syndrome (AIDS), according to a genetic association analysis of 2857 patients enrolled in five AIDS cohort studies. The recessive protective effect of SDF1-3′A was increasingly pronounced in individuals infected with HIV-1 for longer periods, was twice as strong as the dominant genetic restriction of AIDS conferred by CCR5 and CCR2 chemokine receptor variants in these populations, and was complementary with these mutations in delaying the onset of AIDS.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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