Physiological Migration of Hematopoietic Stem and Progenitor Cells-Reference-Cited by-同舟云学术

Physiological Migration of Hematopoietic Stem and Progenitor Cells

Published:2001-11-30 Issue:5548 Volume:294 Page:1933-1936
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Wright Douglas E.¹,Wagers Amy J.¹,Gulati Anjali Pathak²,Johnson Frances L.²,Weissman Irving L.¹

Affiliation:

1. Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

2. Department of Medicine, Cardiovascular Medicine Division, Stanford University School of Medicine, Palo Alto Veterans Affairs Health Care System, Cardiology Section (111C), 3801 Miranda Avenue, Palo Alto, CA 94304, USA.

Abstract

Hematopoietic stem cells (HSCs) reside predominantly in bone marrow, but low numbers of HSCs are also found in peripheral blood. We examined the fate of blood-borne HSCs using genetically marked parabiotic mice, which are surgically conjoined and share a common circulation. Parabionts rapidly established stable, functional cross engraftment of partner-derived HSCs and maintained partner-derived hematopoiesis after surgical separation. Determination of the residence time of injected blood-borne progenitor cells suggests that circulating HSCs/progenitors are cleared quickly from the blood. These data demonstrate that HSCs rapidly and constitutively migrate through the blood and play a physiological role in, at least, the functional reengraftment of unconditioned bone marrow.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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5. C57BL/Ka-Thy-1.1-CD45.2 and C57BL/Ka-Thy-1.1-CD45.1 mice were bred and maintained at the Stanford University Laboratory Animal Facility and given acidified water (pH 2.5) and rodent chow ad libitum. Mice used for parabiosis were male and 2 to 6 months old at the time of surgical joining and mice used for progenitor clearance studies were 6 to 8 weeks old.

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