Antiaging diets: Separating fact from fiction

Abstract

Caution around the fountain of youth The scientific and popular literature is full of claims for diets that delay or reverse the aging process (at least in model organisms). But how do these interventions work? Is it the amount of food, the timing of food intake, the proportion of certain macronutrients? In a Review, Lee et al . explore the fact and fiction of dietary prescriptions for a healthier and longer life. They propose that one unifying concept may be convergence on the signaling pathway mediated by the protein kinase mTOR (mechanistic target of rapamycin). Another conclusion is that the efficacy and safety of these diets for humans largely remain to be established. —LBR