The Role of Endosymbiotic Wolbachia Bacteria in the Pathogenesis of River Blindness-Reference-Cited by-同舟云学术

The Role of Endosymbiotic Wolbachia Bacteria in the Pathogenesis of River Blindness

Published:2002-03-08 Issue:5561 Volume:295 Page:1892-1895
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

André Amélie v. Saint¹,Blackwell Nathan M.¹²,Hall Laurie R.¹,Hoerauf Achim³,Brattig Norbert W.³,Volkmann Lars³,Taylor Mark J.⁴,Ford Louise⁴,Hise Amy G.¹,Lass Jonathan H.²,Diaconu Eugenia²,Pearlman Eric¹²

Affiliation:

1. Division of Geographic Medicine,

2. Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA.

3. Bernhard Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.

4. Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK.

Abstract

Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Wolbachia Bacteria of Filarial Nematodes

2. A. Hoerauf et al. J. Clin. Invest. 103 11 (1999).

3. A. Hoerauf et al. Lancet 355 1242 (2000).

4. www.who.int/ocp/apoc/apoc002.htm (2002).

5. Pathogenesis of Onchocercal Keratitis (River Blindness)

Cited by 309 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Filariases;Manson's Tropical Diseases;2024

2. Presumed Onchocerciasis Chorioretinitis Spilling over into North America, Europe and Middle East;Diagnostics;2023-12-08

3. “Slow kill” treatment reduces DNA damage in leukocytes of dogs naturally infected with Dirofilaria immitis;Veterinary Parasitology;2023-10

4. A Phase-I pharmacokinetic, safety and food-effect study on flubentylosin, a novel analog of Tylosin-A having potent anti-Wolbachia and antifilarial activity;PLOS Neglected Tropical Diseases;2023-07-10

5. A longitudinal survey in the wild reveals major shifts in fish host microbiota after parasite infection;Molecular Ecology;2023-03-10