Nonmethylated Transposable Elements and Methylated Genes in a Chordate Genome-Reference-Cited by-同舟云学术

Nonmethylated Transposable Elements and Methylated Genes in a Chordate Genome

Published:1999-02-19 Issue:5405 Volume:283 Page:1164-1167
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Simmen Martin W.¹,Leitgeb Sabine¹,Charlton Jillian¹,Jones Steven J. M.²,Harris Barbara R.²,Clark Victoria H.¹,Bird Adrian¹

Affiliation:

1. Institute of Cell and Molecular Biology, University of Edinburgh, The King's Buildings, Edinburgh EH9 3JR, UK.

2. The Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

Abstract

The genome of the invertebrate chordate Ciona intestinalis was found to be a stable mosaic of methylated and nonmethylated domains. Multiple copies of an apparently active long terminal repeat retrotransposon and a long interspersed element are nonmethylated and a large fraction of abundant short interspersed elements are also methylation free. Genes, by contrast, are predominantly methylated. These data are incompatible with the genome defense model, which proposes that DNA methylation in animals is primarily targeted to endogenous transposable elements. Cytosine methylation in this urochordate may be preferentially directed to genes.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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