Affiliation:
1. Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Abstract
Crafting chiral boron building blocks
Carbon-boron bonds are easily transformed into a wide variety of C–C, C–N, and C–O bonds. With that flexibility in mind, Schmidt
et al.
show that nickel complexes can catalyze asymmetric alkylation of carbon centers adjacent to boron. This protocol creates chiral alkylboronates that function as stable precursors to numerous complex molecules. The reaction proceeds in stereo-convergent fashion—forming a single product from either mirror image of the α-haloboronate reagent. Successive reactions can also create chains of adjacent chiral alkyl centers with stereochemistry set by the configuration of the ligand bound to nickel.
Science
, this issue p.
1265
Funder
National Institutes of Health
Alexander von Humboldt Foundation
German National Merit Foundation
David S. Koons SURF
Gordon and Betty Moore Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
217 articles.
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