Designer nanoscale DNA assemblies programmed from the top down-Reference-Cited by-同舟云学术

Designer nanoscale DNA assemblies programmed from the top down

Published:2016-06-24 Issue:6293 Volume:352 Page:1534-1534
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Veneziano Rémi¹,Ratanalert Sakul¹²,Zhang Kaiming³,Zhang Fei⁴⁵,Yan Hao⁴⁵,Chiu Wah³,Bathe Mark¹

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

2. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

4. School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA.

5. Biodesign Center for Molecular Design and Biomimetics (at the Biodesign Institute) at Arizona State University, Tempe, AZ 85287, USA.

Abstract

Simplifying DNA origami design Many intricate nanostructures have been made with DNA origami. This process occurs when a long DNA scaffold develops a particular shape after hybridization with short staple strands. Most designs, however, require a difficult iterative procedure of refining the base pairing. Veneziano et al. now report algorithms that automate the design of arbitrary DNA wireframe structures. Synthesizing and structurally characterizing a variety of nanostructures allowed for verification of the algorithms' accuracy. Science , this issue p. 1534

Funder

Office of Naval Research

Human Frontier Science Program (HFSP)

National Science Foundation (NSF-EAGER)

National Science Foundation (NSF CMMI)

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference63 articles.

1. Nucleic acid junctions and lattices