Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation-Reference-Cited by-同舟云学术

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

Published:2010-01-15 Issue:5963 Volume:327 Page:348-351
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rihel Jason¹,Prober David A.¹,Arvanites Anthony²,Lam Kelvin²,Zimmerman Steven¹,Jang Sumin¹,Haggarty Stephen J.³⁴⁵,Kokel David⁶,Rubin Lee L.²,Peterson Randall T.³⁶⁷,Schier Alexander F.¹²³⁸⁹

Affiliation:

1. Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.

2. Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.

3. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

4. Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

5. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.

6. Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.

7. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

8. Division of Sleep Medicine, Harvard Medical School, Boston, MA 02215, USA.

9. Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

Abstract

Behavioral Profiling The complexity of the brain makes it difficult to predict how a drug will affect behavior without direct testing in live animals. Rihel et al. (p. 348 ) developed a high-throughput assay to assess the effects of thousands of drugs on sleep/wake behaviors of zebrafish larvae. The data set reveals a broad conservation of zebrafish and mammalian sleep/wake pharmacology and identifies pathways that regulate sleep. Moreover, the biological targets of poorly characterized small molecules can be predicted by matching their behavioral profiles to those of well-known drugs. Thus, behavioral profiling in zebrafish offers a cost-effective way to characterize neuroactive drugs and to predict biological targets of novel compounds.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. How can drug discovery for psychiatric disorders be improved?

2. Drug development for CNS disorders: strategies for balancing risk and reducing attrition

3. Discovery and Use of Small Molecules for Probing Biological Processes in Zebrafish

4. A Chemical Genetic Screen for Cell Cycle Inhibitors in Zebrafish Embryos

5. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

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