Mutated clones are the new normal-Reference-Cited by-同舟云学术

Mutated clones are the new normal

Published:2019-06-07 Issue:6444 Volume:364 Page:938-939
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tomasetti Cristian¹

Affiliation:

1. Division of Biostatistics and Bioinformatics, Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, and Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Abstract

Measuring and understanding the dynamics of clonal cell populations is key for cancer prevention

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference17 articles.

1. RNA sequence analysis reveals macroscopic somatic clonal expansion across normal tissues

2. Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

3. Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

5. High burden and pervasive positive selection of somatic mutations in normal human skin

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