Transcriptional Regulatory Networks in Saccharomyces cerevisiae

Author:

Lee Tong Ihn1,Rinaldi Nicola J.12,Robert François1,Odom Duncan T.1,Bar-Joseph Ziv3,Gerber Georg K.3,Hannett Nancy M.1,Harbison Christopher T.12,Thompson Craig M.1,Simon Itamar1,Zeitlinger Julia1,Jennings Ezra G.12,Murray Heather L.1,Gordon D. Benjamin1,Ren Bing1,Wyrick John J.1,Tagne Jean-Bosco1,Volkert Thomas L.1,Fraenkel Ernest1,Gifford David K.3,Young Richard A.12

Affiliation:

1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.

2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

3. MIT Laboratory of Computer Science, 200 Technology Square, Cambridge, MA 02139, USA.

Abstract

We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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