The form and function of channelrhodopsin-Reference-Cited by-同舟云学术

The form and function of channelrhodopsin

Published:2017-09-15 Issue:6356 Volume:357 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Deisseroth Karl¹²³^ORCID,Hegemann Peter⁴⁵

Affiliation:

1. Department of Bioengineering, Stanford University, Stanford, CA, USA.

2. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.

3. Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.

4. Institute for Biology, Humboldt Universität zu Berlin, D-10115 Berlin, Germany.

5. Experimental Biophysics, Humboldt Universität zu Berlin, D-10115 Berlin, Germany.

Abstract

From biophysics to neuroscience tools The channelrhodopsins and their distinctive light-activated ion channels have emerged as major tools in modern biological research. Deisseroth and Hegemann review the structural and functional properties of these protein photoreceptors. Mutagenesis and modeling studies, coupled with the reintroduction of modified channels into living systems, offer a profound understanding of how these channels work. The insights into the underlying basic science provide foundations for developing further applications in biology and medicine. Science , this issue p. eaan5544

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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