Cospeciation of gut microbiota with hominids

Author:

Moeller Andrew H.12,Caro-Quintero Alejandro3,Mjungu Deus4,Georgiev Alexander V.56,Lonsdorf Elizabeth V.7,Muller Martin N.8,Pusey Anne E.9,Peeters Martine10,Hahn Beatrice H.11,Ochman Howard1

Affiliation:

1. Department of Integrative Biology, 2506 Speedway A5000, University of Texas at Austin, Austin, TX 78712, USA.

2. Miller Institute for Basic Research in Science, 2536 Channing Way, University of California, Berkeley, CA 94720, USA.

3. Corpoicá C.I Tibaitata, Santa Fe de Bogotá, Bogotá, Colombia.

4. Gombe Stream Research Center, Kigoma, Tanzania.

5. Department of Anthropology, Northwestern University, 1810 Hinman Avenue, Evanston, IL 60208, USA.

6. Department of Human Evolutionary Biology, Harvard University, 11 Divinity Avenue, Cambridge, MA 02138, USA.

7. Department of Psychology and Biological Foundations of Behavior Program, LSP 261B, Franklin and Marshall College, Lancaster, PA 17603, USA.

8. Department of Anthropology, University of New Mexico, MSC01-1040, Albuquerque, NM 87131, USA.

9. Department of Evolutionary Anthropology, 101 Biological Sciences Building, Duke University, Durham, NC 27708, USA.

10. Institut de Recherche pour le Développement, University of Montpellier, 34394 Montpellier, France.

11. Departments of Medicine and Microbiology, Perelman School of Medicine, 409 Johnson Pavilion, University of Pennsylvania, Philadelphia, PA 19104, USA.

Abstract

Human-microbiota coevolution The bacteria that make their home in the intestines of modern apes and humans arose from ancient bacteria that colonized the guts of our common ancestors. Moeller et al. have developed a method to compare rapidly evolving gyrB gene sequences in fecal samples from humans and wild chimpanzees, bonobos, and gorillas (see the Perspective by Segre and Salafsky). Comparison of the gyrB phylogenies of major bacterial lineages reveals that they mostly match the apehominid phylogeny, except for some rare symbiont transfers between primate species. Gut bacteria therefore are not simply acquired from the environment, but have coevolved for millions of years with hominids to help shape our immune systems and development. Science , this issue p. 380 ; see also p. 350

Funder

NIH

NSF

Agence Nationale de Recherche sur le Sida

Jane Goodall Institute

Arthur L. Greene Fund

Harvard University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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