AIDS as a Zoonosis: Scientific and Public Health Implications

Author:

Hahn Beatrice H.1,Shaw George M.12,De Kevin M.,Cock 3,Sharp Paul M.4

Affiliation:

1. Departments of Medicine and Microbiology,

2. Howard Hughes Medical Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

3. Division of HIV/AIDS Prevention–Surveillance and Epidemiology, National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

4. Institute of Genetics, University of Nottingham, Queens Medical Centre, Nottingham NH7 2UH, UK.

Abstract

Evidence of simian immunodeficiency virus (SIV) infection has been reported for 26 different species of African nonhuman primates. Two of these viruses, SIVcpz from chimpanzees and SIVsm from sooty mangabeys, are the cause of acquired immunodeficiency syndrome (AIDS) in humans. Together, they have been transmitted to humans on at least seven occasions. The implications of human infection by a diverse set of SIVs and of exposure to a plethora of additional human immunodeficiency virus–related viruses are discussed.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference96 articles.

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2. AIDS Epidemic Update: December 1999 (UNAIDS Geneva 1999) www.unaids.org.

3. Human Retroviruses and AIDS 1998: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences (Los Alamos National Laboratory Los Alamos NM 1998) .

4. Gao F., et al., Nature 397, 436 (1999).

5. Gao F., et al., Nature 358, 495 (1992);

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