Affiliation:
1. Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
Abstract
A cytochrome c oxidase model that consists of a cobalt(II) porphyrin with a copper(I) triazacyclononane macrocycle fastened on the distal face and an imidazole covalently attached to the proximal face has been synthesized and characterized. Redox titrations with molecular oxygen (O
2
) and cobaltocene were carried out, and O
2
was found to bind irreversibly in a 1:1 ratio to the model compound. This O
2
adduct (a bridged peroxide) can be fully reduced to the deoxygenated form with four equivalents of cobaltocene. The model compound was adsorbed on an edge-plane graphite electrode, and rotating ring-disk voltammetry was used to monitor the electrocatalytic reduction of O
2
. Four-electron reduction of O
2
was observed at physiological pH.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
189 articles.
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