Affiliation:
1. Laboratoire de Microbiologie et Génétique Moléculaires, UMR 5100 CNRS-Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse Cedex 9, France.
Abstract
Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in
Streptococcus pneumoniae
. This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of
recA
was strictly dependent on the development of competence. In response to antibiotic stress,
S. pneumoniae
, which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
376 articles.
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