Influenza A virus uses the aggresome processing machinery for host cell entry-Reference-Cited by-同舟云学术

Influenza A virus uses the aggresome processing machinery for host cell entry

Published:2014-10-24 Issue:6208 Volume:346 Page:473-477
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Banerjee Indranil¹,Miyake Yasuyuki²,Nobs Samuel Philip³,Schneider Christoph³,Horvath Peter⁴,Kopf Manfred³,Matthias Patrick²⁵,Helenius Ari¹,Yamauchi Yohei¹

Affiliation:

1. Institute of Biochemistry, Eidgenossische Technische Hochschule (ETH) Zurich, Switzerland.

2. Epigenetics, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

3. Institute of Molecular Health Sciences, ETH Zurich, Switzerland.

4. Synthetic and Systems Biology Unit, Biological Research Center, Szeged, Hungary.

5. Faculty of Sciences, University of Basel, Basel, Switzerland.

Abstract

Flu mimics damaged proteins during entry Viruses are master manipulators. The early stages of how flu viruses enter cells are very well understood, but Banerjee et al. describe a new wrinkle (see the Perspective by Rajsbaum and García-Sastre). It seems that the virus carries with it into the cell ubiquitin: a molecule involved in marking proteins for destruction. The virus then exploits host cell machinery involved in recognizing and dealing with damaged proteins to uncoat its own RNA genome, ready to continue its path toward successful infection. Science , this issue p. 473 ; see also p. 427

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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