Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Author:

Santarelli Luca1234,Saxe Michael1234,Gross Cornelius1234,Surget Alexandre1234,Battaglia Fortunato1234,Dulawa Stephanie1234,Weisstaub Noelia1234,Lee James1234,Duman Ronald1234,Arancio Ottavio1234,Belzung Catherine1234,Hen René1234

Affiliation:

1. Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

2. Psychobiologie des Emotions, Université François Rabelais, Tours 37200, France.

3. Nathan Kline Research Institute, New York University School of Medicine, New York, NY 10016, USA.

4. Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, CT 06508, USA.

Abstract

Various chronic antidepressant treatments increase adult hippocampal neurogenesis, but the functional importance of this phenomenon remains unclear. Here, using genetic and radiological methods, we show that disrupting antidepressant-induced neurogenesis blocks behavioral responses to antidepressants. Serotonin 1A receptor null mice were insensitive to the neurogenic and behavioral effects of fluoxetine, a serotonin selective reuptake inhibitor. X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants. These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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