Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor-Reference-Cited by-同舟云学术

Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor

Published:2013-02 Issue:6119 Volume:339 Page:548-554
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Smith Michelle I.¹,Yatsunenko Tanya¹,Manary Mark J.²³⁴,Trehan Indi²³,Mkakosya Rajhab⁵,Cheng Jiye¹,Kau Andrew L.¹,Rich Stephen S.⁶,Concannon Patrick⁶,Mychaleckyj Josyf C.⁶,Liu Jie⁷,Houpt Eric⁷,Li Jia V.⁸,Holmes Elaine⁸,Nicholson Jeremy⁸,Knights Dan⁹¹⁰,Ursell Luke K.¹¹,Knight Rob⁹¹⁰¹¹¹²,Gordon Jeffrey I.¹

Affiliation:

1. Center for Genome Sciences and Systems Biology, Washington University in St. Louis, St. Louis, MO 63110, USA.

2. Department of Pediatrics, Washington University in St. Louis, St. Louis, MO 63110, USA.

3. Department of Community Health and Department of Pediatrics and Child Health, University of Malawi College of Medicine, Blantyre, Malawi.

4. U.S. Department of Agriculture Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA.

5. Department of Microbiology, College of Medicine, University of Malawi, P/B 360, Chichiri, Blantyre 3, Malawi.

6. Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22904, USA.

7. Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908, USA.

8. Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.

9. Department of Computer Science, University of Colorado, Boulder, CO 80309, USA.

10. Biofrontiers Institute, University of Colorado, Boulder, CO 80309, USA.

11. Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.

12. Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.

Abstract

Not Just Wasting Malnutrition is well known in Malawi, including a severe form—kwashiorkor—in which children do not simply waste away, they also suffer edema, liver damage, skin ulceration, and anorexia. Smith et al. (p. 548 ; see the Perspective by

Relman

) investigated the microbiota of pairs of twins in Malawian villages and found notable differences in the composition of the gut microbiota in children with kwashiorkor. In these children, a bacterial species related to Desulfovibrio , which has been associated with bowel disease and inflammation, was noticeable. When the fecal flora from either the healthy or the sick twin was transplanted into groups of germ-free mice, the mice that received the kwashiorkor sample started to lose weight, like their human counterpart.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

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3. WHO UN Children's Fund WHO Child Growth Standards and the Identification of Severe Acute Malnutrition in Infants and Children (2009); www.who.int/nutrition/publications/severemalnutrition/9789241598163/en/index.html.

4. KWASHIORKOR

5. Oedematous malnutrition;Ahmed T.;Indian J. Med. Res.,2009

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