Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis-Reference-Cited by-同舟云学术

Planar Cell Polarity Acts Through Septins to Control Collective Cell Movement and Ciliogenesis

Published:2010-09-10 Issue:5997 Volume:329 Page:1337-1340
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kim Su Kyoung¹,Shindo Asako¹,Park Tae Joo¹,Oh Edwin C.²,Ghosh Srimoyee¹,Gray Ryan S.¹,Lewis Richard A.³,Johnson Colin A.⁴,Attie-Bittach Tania⁵,Katsanis Nicholas²,Wallingford John B.¹⁶

Affiliation:

1. Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA.

2. Center for Human Disease Modeling, Departments of Cell Biology and Pediatrics, Duke University, Durham, NC 27710, USA.

3. Departments of Ophthalmology, Medicine, Pediatrics, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

4. Sections of Ophthalmology and Neurosciences, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, LS9 7TF, UK.

5. Département de Génétique, INSERM U781, Hôpital Necker–Enfants Malades, Université Paris Descartes, Paris, France.

6. Howard Hughes Medical Institute, University of Texas at Austin, Austin, TX 78712, USA.

Abstract

Form and Function The Planar Cell Polarity (PCP) signaling pathway governs cell movements that drive axis elongation and neural tube closure in vertebrate embryos, and certain vertebrate PCP proteins have also been implicated in ciliogenesis. Likewise, the septin cytoskeleton controls diverse cell behaviors, such as cytokinesis and cell migration, but little is known about how septin functions are regulated in vivo. Kim et al. (p. 1337 , published online 29 July; see the Perspective by

Barral

) found that control of septins by the PCP effector protein, Fritz, was a crucial control point for morphogenesis and ciliogenesis. During neural tube closure, Fritz-mediated septin localization maintained cell shape but not cell polarity. In ciliated epithelial cells, Fritz was required for assembly of the septin rings at the base of cilia, which are needed for normal ciliogenesis and signaling.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

1. J. P. Trinkaus Cell Into Organs—The Forces That Shape the Embryo (Prentice-Hall Englewood Cliffs NJ 1969).

2. Cell motility driving mediolateral intercalation in explants of Xenopus laevis

3. The cellular basis of the convergence and extension of the Xenopus neural plate

4. Shaping the Vertebrate Body Plan by Polarized Embryonic Cell Movements

5. Neural tube closure requires Dishevelled-dependent convergent extension of the midline

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