Regulation of Chromatin Remodeling by Inositol Polyphosphates-Reference-Cited by-同舟云学术

Regulation of Chromatin Remodeling by Inositol Polyphosphates

Published:2003-01-03 Issue:5603 Volume:299 Page:114-116
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Steger David J.¹,Haswell Elizabeth S.¹,Miller Aimee L.²,Wente Susan R.²,O'Shea Erin K.¹

Affiliation:

1. Department of Biochemistry and Biophysics, Howard Hughes Medical Institute, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143–0448, USA.

2. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 3120A MRBIII, Nashville, TN 37212, USA.

Abstract

Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in induction of the phosphate-responsive PHO5 gene, we identified mutations in ARG82/IPK2 , which encodes a nuclear inositol polyphosphate kinase. In arg82 mutant strains, remodeling of PHO5 promoter chromatin is impaired, and the adenosine triphosphate–dependent chromatin-remodeling complexes SWI/SNF and INO80 are not efficiently recruited to phosphate-responsive promoters. These results suggest a role for the small molecule inositol polyphosphate in the regulation of chromatin remodeling and transcription.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Translating the Histone Code

2. Cooperation between Complexes that Regulate Chromatin Structure and Transcription

3. The phosphatase system in Saccharomyces cerevisiae.

4. Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85

5. Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4

Cited by 326 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Genomic approachesidentifySTT4 as a new component in glucose-induced activation of yeast plasma membrane H+-ATPase;Cell Calcium;2024-11

2. Design, synthesis and cellular characterization of a new class of IPMK kinase inhibitors;2024-05-14

3. Nuclear patterns of phosphatidylinositol 4,5‐ and 3,4‐bisphosphate revealed by super‐resolution microscopy differ between the consecutive stages of RNA polymerase II transcription;The FEBS Journal;2024-05-11

4. The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1;Journal of Biological Chemistry;2024-02

5. Aldo-keto reductase 1B: Much learned, much more to do;hLife;2023-12