Intersection of population variation and autoimmunity genetics in human T cell activation-Reference-Cited by-同舟云学术

Intersection of population variation and autoimmunity genetics in human T cell activation

Published:2014-09-12 Issue:6202 Volume:345 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ye Chun Jimmie¹,Feng Ting²,Kwon Ho-Keun²,Raj Towfique¹³,Wilson Michael T.²,Asinovski Natasha²,McCabe Cristin¹³,Lee Michelle H.³,Frohlich Irene³,Paik Hyun-il²,Zaitlen Noah⁴,Hacohen Nir²,Stranger Barbara⁵,De Jager Philip¹³,Mathis Diane¹²,Regev Aviv¹⁶,Benoist Christophe¹²

Affiliation:

1. Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.

2. Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.

3. Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women’s Hospital, Boston, MA 02115, USA.

4. Department of Medicine Lung Biology Center, University of California, San Francisco, San Francisco, CA 94158, USA.

5. Section of Genetic Medicine, University of Chicago, Chicago, IL 60637, USA.

6. Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.

Abstract

Response to pathogens is in the genes T cells are important in mounting immune responses to a host of pathogens, and they have also been implicated in autoimmune disease. By examining the variability in gene expression in stimulated T cells over time from a multi-ethnic cohort of healthy humans, Ye et al. identified specific genetic polymorphisms that explain differences among individuals in response to pathogens. Furthermore, a candidate gene approach led to the identification of a single-nucleotide polymorphism that controls the response of the autoimmune-associated IL2RA gene. This study helps us understand the degree to which immune responses are driven by the environment or by an individual's physiological or genetic factors. Science , this issue 10.1126/science.1254665

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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