The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells-Reference-Cited by-同舟云学术

The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells

Published:2004-11-19 Issue:5700 Volume:306 Page:1380-1383
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Elphick Gwendolyn F.¹²³⁴,Querbes William¹²³⁴,Jordan Joslynn A.¹²³⁴,Gee Gretchen V.¹²³⁴,Eash Sylvia¹²³⁴,Manley Kate¹²³⁴,Dugan Aisling¹²³⁴,Stanifer Megan¹²³⁴,Bhatnagar Anushree¹²³⁴,Kroeze Wesley K.¹²³⁴,Roth Bryan L.¹²³⁴,Atwood Walter J.¹²³⁴

Affiliation:

1. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

2. Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA.

3. Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

4. Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA.

Abstract

The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor 5HT 2A R could act as the cellular receptor for JCV on human glial cells. The 5HT 2A receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT 2A receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT 2A receptor–negative HeLa cells with a 5HT 2A receptor rescued virus infection, and this infection was blocked by antibody to the 5HT 2A receptor. A tagged 5HT 2A receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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