The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells-Reference-Cited by-同舟云学术

The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells

Published:2004-11-19 Issue:5700 Volume:306 Page:1380-1383
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Elphick Gwendolyn F.¹²³⁴,Querbes William¹²³⁴,Jordan Joslynn A.¹²³⁴,Gee Gretchen V.¹²³⁴,Eash Sylvia¹²³⁴,Manley Kate¹²³⁴,Dugan Aisling¹²³⁴,Stanifer Megan¹²³⁴,Bhatnagar Anushree¹²³⁴,Kroeze Wesley K.¹²³⁴,Roth Bryan L.¹²³⁴,Atwood Walter J.¹²³⁴

Affiliation:

1. Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

2. Graduate Program in Pathobiology, Brown University, Providence, RI 02912, USA.

3. Graduate Program in Molecular Biology, Cellular Biology, and Biochemistry, Brown University, Providence, RI 02912, USA.

4. Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, Ohio 44106, USA.

Abstract

The human polyomavirus, JCV, causes the fatal demyelinating disease progressive multifocal leukoencephalopathy in immunocompromised patients. We found that the serotonergic receptor 5HT 2A R could act as the cellular receptor for JCV on human glial cells. The 5HT 2A receptor antagonists inhibited JCV infection, and monoclonal antibodies directed at 5HT 2A receptors blocked infection of glial cells by JCV, but not by SV40. Transfection of 5HT 2A receptor–negative HeLa cells with a 5HT 2A receptor rescued virus infection, and this infection was blocked by antibody to the 5HT 2A receptor. A tagged 5HT 2A receptor colocalized with labeled JCV in an endosomal compartment following internalization. Serotonin receptor antagonists may thus be useful in the treatment of progressive multifocal leukoencephalopathy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Progressive Multifocal Leukoencephalopathy in the United States, 1979–1994: Increased Mortality Associated with HIV Infection

2. D. L. Walker, R. J. Frisque, in The Papovaviridae, N. P. Salzman, ed. (Plenum, New York and London, 1986), pp. 327–377.

3. Documenting the Epidemiologic Patterns of Polyomaviruses in Human Populations by Studying Their Presence in Urban Sewage

4. Progressive Multifocal Leukoencephalopathy

5. Involvement of JC Virus–Infected Mononuclear Cells from the Bone Marrow and Spleen in the Pathogenesis of Progressive Multifocal Leukoencephalopathy

Cited by 383 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Progressive multifocal leukoencephalopathy in sarcoidosis successfully treated with pembrolizumab;Journal of NeuroVirology;2024-08-18

2. Unveiling the Enigma: John Cunningham Virus-Associated Progressive Multifocal Leukoencephalopathy in an Immunocompetent Individual;Cureus;2024-07-17

3. Hemorrhagic cystitis induced by JC polyomavirus infection following COVID-19: a case report;BMC Urology;2024-04-16

4. CNS Viral Infections—What to Consider for Improving Drug Treatment: A Plea for Using Mathematical Modeling Approaches;CNS Drugs;2024-04-05

5. High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection;Antiviral Research;2024-02