X-ray Crystal Structures of 70 S Ribosome Functional Complexes-Reference-Cited by-同舟云学术

X-ray Crystal Structures of 70 S Ribosome Functional Complexes

Published:1999-09-24 Issue:5436 Volume:285 Page:2095-2104
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cate Jamie H.¹,Yusupov Marat M.¹,Yusupova Gulnara Zh.¹,Earnest Thomas N.²,Noller Harry F.¹

Affiliation:

1. Center for Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz, CA 95064, USA.

2. Macromolecular Crystallography Facility, Advanced Light Source, Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Abstract

Structures of 70 S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of the interactions between tRNA and the ribosome, and of the packing arrangements of ribosomal RNA (rRNA) helices in and between the ribosomal subunits, can be seen. Numerous contacts are made between the 30 S subunit and the P-tRNA anticodon stem-loop; in contrast, the anticodon region of A-tRNA is much more exposed. A complex network of molecular interactions suggestive of a functional relay is centered around the long penultimate stem of 16 S rRNA at the subunit interface, including interactions involving the “switch” helix and decoding site of 16 S rRNA, and RNA bridges from the 50 S subunit.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference135 articles.

1. Woese C. R., et al., Microbiol. Rev. 47, 621 (1983).

2. W. E. Hill et al. Eds. The Ribosome: Structure Function and Evolution (American Society for Microbiology Washington DC 1990).

3. Watson J. D., Bull. Soc. Chim. Biol. 46, 1399 (1964).

4. Rheinberger H. J., Sternbach H., Nierhaus K. H., Proc. Natl. Acad. Sci. U.S.A. 78, 5310 (1981).

5. Monro R. E., J. Mol. Biol. 26, 147 (1967).

Cited by 544 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pioneering role of RNA in the early evolution of life;Genetics and Molecular Biology;2024

2. High-Resolution Structure and Internal Mobility of a Plant 40S Ribosomal Subunit;International Journal of Molecular Sciences;2023-12-14

3. Translation machinery captured in motion;WIREs RNA;2023-05-03

4. General Strategies for RNA X-ray Crystallography;Molecules;2023-02-23

5. Aminoglycoside antibiotics;Antibiotics - Therapeutic Spectrum and Limitations;2023