Affiliation:
1. Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA.
Abstract
Notch role in multipotency or cell fate
Multipotent
Drosophila
intestinal stem cells (ISCs) generate either nutrient-absorbing enterocytes (ECs) or secretory enteroendocrine cells (EECs). Guo and Ohlstein investigated the role of Notch signaling in this process. They tracked ISC asymmetric divisions and found that EEC daughter cells, which have a low level of Notch, signal back to the ISC in order to keep it multipotent. However, during EC production, ISCs activate strong Notch signaling in daughters. Thus, Notch signaling functions in two directions to achieve stem cell multipotency.
Science
, this issue p.
10.1126/science.aab0988
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
160 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献