The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin-Reference-Cited by-同舟云学术

The Structure of a Complex of Recombinant Hirudin and Human α-Thrombin

Published:1990-07-20 Issue:4966 Volume:249 Page:277-280
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rydel Timothy J.¹,Ravichandran K. G.¹,Tulinsky A.¹,Bode Wolfram²,Huber Robert²,Roitsch Carolyn³,Fenton John W.⁴

Affiliation:

1. Department of Chemistry, Michigan State University, East Lansing, MI 48824.

2. Max-Planck-Institut für Biochemie, D-8033 Martinsried, Federal Republic of Germany.

3. Transgene S.A., 67082 Strasbourg Cedex, France.

4. Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany, NY 12201, and Departrnents of Physiology and Biochemistry, The Albany Medical College of Union University, Albany, NY 12208.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference38 articles.

1. BODE, W, THE REFINED 1.9 A CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN - INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT, EMBO JOURNAL 8: 3467 (1989).

2. BODE, W, THE REFINED 2.0 A X-RAY CRYSTAL-STRUCTURE OF THE COMPLEX FORMED BETWEEN BOVINE BETA-TRYPSIN AND CMTI-I, A TRYPSIN-INHIBITOR FROM SQUASH SEEDS (CUCURBITA-MAXIMA) - TOPOLOGICAL SIMILARITY OF THE SQUASH SEED INHIBITORS WITH THE CARBOXYPEPTIDASE A INHIBITOR FROM POTATOES, FEBS LETTERS 242: 285 (1989).

3. BRAUN, P.J., USE OF SITE-DIRECTED MUTAGENESIS TO INVESTIGATE THE BASIS FOR THE SPECIFICITY OF HIRUDIN, BIOCHEMISTRY 27: 6517 (1988).

4. BUTKOWSKI, R.J., PRIMARY STRUCTURE OF HUMAN PRETHROMBIN-2 AND ALPHA-THROMBIN, JOURNAL OF BIOLOGICAL CHEMISTRY 252: 4942 (1977).

5. CHANG, J.Y., THROMBIN SPECIFICITY - REQUIREMENT FOR APOLAR AMINO-ACIDS ADJACENT TO THE THROMBIN CLEAVAGE SITE OF POLYPEPTIDE SUBSTRATE, EUROPEAN JOURNAL OF BIOCHEMISTRY 151: 217 (1985).

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