Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation

Author:

Wolozin Benjamin1,Iwasaki Katsunori1,Vito Pasquale2,Ganjei J. Kelly2,Lacanà Emanuela2,Sunderland Trey1,Zhao Boyu3,Kusiak John W.3,Wasco Wilma4,D'Adamio Luciano5

Affiliation:

1. B. Wolozin, K. Iwasaki, T. Sunderland, Unit on Alzheimer Biology, Laboratory of Clinical Science, National Institute of Mental Health, Building 10, Room 3D41, 9000 Rockville Pike, Bethesda, MD 20892, USA.

2. P. Vito, J. K. Ganjei, E. Lacanà, T-Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, Building 4, Room 431, 9000 Rockville Pike, Bethesda, MD 20892, USA.

3. B. Zhao and J. W. Kusiak, Molecular Neurobiology Unit, National Institute of Aging, Cellular Neurobiology Branch, National Institute of Neurological Disorders and Stroke, Gerontology Research Center, 4940 Eastern Avenue, Baltimore, MD 21224, USA.

4. W. Wasco, Genetics and Aging Unit, Department of Neurology, Massachusetts General Hospital-East, Harvard Medical School, 149 13th Street, Charlestown, MA 02139, USA.

5. L. D'Adamio, T-Cell Molecular Biology Unit, Laboratory of Cellular and Molecular Immunology, National Institutes of Health, Building 4, Room 111, 9000 Rockville Pike, Bethesda, MD 20892, USA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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