T-Independent Immune Response: New Aspects of B Cell Biology-Reference-Cited by-同舟云学术

T-Independent Immune Response: New Aspects of B Cell Biology

Published:2000-10-06 Issue:5489 Volume:290 Page:89-92
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fagarasan Sidonia¹,Honjo Tasuku¹

Affiliation:

1. Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

Abstract

Recent results emphasize the roles of T-independent antibody response in humoral defenses, for which B1 cells and marginal zone B cells are mostly responsible. We discuss how these cells are activated, migrate, and differentiate into antibody-producing cells in various lymphoid tissues. Based on recent findings in each of these areas of B cell biology, we propose a possible mechanism for peripheral tolerance of autoreactive B cells at target organs.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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