Affiliation:
1. Department of Cardiology, Howard Hughes Medical Institute, Children's Hospital Boston, Manton Center for Orphan Disease, and Department of Neurobiology, Harvard Medical School, Enders Building 1309, 320 Longwood Avenue, Boston, MA 02115, USA.
Abstract
In and Out
For over 40 years, Ca
2+
/H
+
antiport has been reported across plasma cell membranes and mitochondrial inner membranes, but the molecules responsible for the exchange have not been known.
Jiang
et al.
(p.
144
; see the Perspective by
Demaurex and Poburko
) conducted a genome-wide RNA interference screen in
Drosophila
and identified a nuclear-encoded mitochondrial protein, Letm1 (leucine zipper EF–hand-containing transmembrane protein 1), as a mitochondrial Ca
2+
/H
+
antiporter critical for mitochondrial Ca
2+
uptake. Furthermore, the gene's mammalian homolog is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by mental retardation, microcephaly, seizures, hypotonia, and cleft lip or palate.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
461 articles.
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