Signaling of Cell Fate Decisions by CLAVATA3 in Arabidopsis Shoot Meristems

Abstract

In higher plants, organogenesis occurs continuously from self-renewing apical meristems. Arabidopsis thaliana plants with loss-of-function mutations in the CLAVATA (CLV1 , 2 , and 3) genes have enlarged meristems and generate extra floral organs. Genetic analysis indicates that CLV1 , which encodes a receptor kinase, acts with CLV3 to control the balance between meristem cell proliferation and differentiation. CLV3 encodes a small, predicted extracellular protein. CLV3 acts nonautonomously in meristems and is expressed at the meristem surface overlying the CLV1 domain. These proteins may act as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions.