Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly-Reference-Cited by-同舟云学术

Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly

Published:2001-04-06 Issue:5514 Volume:292 Page:110-113
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nakayama Jun-ichi¹,Rice Judd C.²,Strahl Brian D.²,Allis C. David²,Grewal Shiv I. S.¹

Affiliation:

1. Cold Spring Harbor Laboratory, Post Office Box 100, Cold Spring Harbor, NY 11724, USA.

2. Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

The assembly of higher order chromatin structures has been linked to the covalent modifications of histone tails. We provide in vivo evidence that lysine 9 of histone H3 (H3 Lys 9 ) is preferentially methylated by the Clr4 protein at heterochromatin-associated regions in fission yeast. Both the conserved chromo- and SET domains of Clr4 are required for H3 Lys 9 methylation in vivo. Localization of Swi6, a homolog of Drosophila HP1, to heterochomatic regions is dependent on H3 Lys 9 methylation. Moreover, an H3-specific deacetylase Clr3 and a β-propeller domain protein Rik1 are required for H3 Lys 9 methylation by Clr4 and Swi6 localization. These data define a conserved pathway wherein sequential histone modifications establish a “histone code” essential for the epigenetic inheritance of heterochromatin assembly.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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