Asymmetric Tethering of Flat and Curved Lipid Membranes by a Golgin

Author:

Drin Guillaume12,Morello Vincent12,Casella Jean-François12,Gounon Pierre12,Antonny Bruno12

Affiliation:

1. Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis and CNRS, 660 route des lucioles, 06560 Valbonne, France.

2. Centre Commun de Microscopie Appliquée, Parc Valrose, 06108 Nice Cedex 2, France.

Abstract

Golgins, long stringlike proteins, tether cisternae and transport vesicles at the Golgi apparatus. We examined the attachment of golgin GMAP-210 to lipid membranes. GMAP-210 connected highly curved liposomes to flatter ones. This asymmetric tethering relied on motifs that sensed membrane curvature both in the N terminus of GMAP-210 and in ArfGAP1, which controlled the interaction of the C terminus of GMAP-210 with the small guanine nucleotide–binding protein Arf1. Because membrane curvature constantly changes during vesicular trafficking, this mode of tethering suggests a way to maintain the Golgi architecture without compromising membrane flow.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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