Affiliation:
1. Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Abstract
In contrast to naïve T cells that recognize short antigen-derived peptides displayed by specialized antigen-presenting cells, immunoglobulin receptors of B lymphocytes primarily recognize intact proteins. How and where within a lymph node such unprocessed antigens become available for naïve B cell recognition is not clear. We used two-photon intravital imaging to show that, after exiting high-endothelial venules and before entry into lymph node follicles, B cells survey locally concentrated dendritic cells. Engagement of the B cell receptor by the dendritic cell (DC)–associated antigen leads to lymphocyte calcium signaling, migration arrest, antigen acquisition, and extrafollicular accumulation. These findings suggest a possible role for antigen-specific B-DC interactions in promoting T cell–dependent antibody responses in vivo.
Publisher
American Association for the Advancement of Science (AAAS)
Reference31 articles.
1. Dendritic cells and the control of immunity
2. C. Drinker, B. Wislocki, M. E. Field, Anat. Rec.56, 261 (1935).
3. A. O. Anderson, N. D. Anderson, Am. J. Pathol.80, 387 (1975).
4. Lymph-Borne Chemokines and Other Low Molecular Weight Molecules Reach High Endothelial Venules via Specialized Conduits While a Functional Barrier Limits Access to the Lymphocyte Microenvironments in Lymph Node Cortex
5. M. Wykes, A. Pombo, C. Jenkins, G. G. MacPherson, J. Immunol.161, 1313 (1998).
Cited by
446 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献