A Human-Specific Gene in Microglia-Reference-Cited by-同舟云学术

A Human-Specific Gene in Microglia

Published:2005-09-09 Issue:5741 Volume:309 Page:1693-1693
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hayakawa Toshiyuki¹²³⁴⁵,Angata Takashi¹²³⁴⁵,Lewis Amanda L.¹²³⁴⁵,Mikkelsen Tarjei S.¹²³⁴⁵,Varki Nissi M.¹²³⁴⁵,Varki Ajit¹²³⁴⁵

Affiliation:

1. Glycobiology Research and Training Center, University of California at San Diego, La Jolla, CA 92093, USA.

2. Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

3. Department of Biological Sciences, University of California at San Diego, La Jolla, CA 92093, USA.

4. Department of Pathology, University of California at San Diego, La Jolla, CA 92093, USA.

5. Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

Abstract

Recent studies have shown multiple differences between humans and apes in sialic acid (Sia) biology, including Siglecs (Sia-recognizing-Ig-superfamily lectins). Comparisons with the chimpanzee genome indicate that human SIGLEC11 emerged through human-specific gene conversion by an adjacent pseudogene. Conversion involved 5� untranslated sequences and the Sia-recognition domain. This human protein shows reduced binding relative to the ancestral form but recognizes oligosialic acids, which are enriched in the brain. SIGLEC11 is expressed in human but not in chimpanzee brain microglia. Further studies will determine if this event was related to the evolution of Homo .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference7 articles.

1. How to make an ape brain

2. Nature

3. Glycobiology

4. Materials and methods are available as supporting material on Science Online .

5. Cloning and Characterization of Human Siglec-11

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