Dynamic control of plant water use using designed ABA receptor agonists

Author:

Vaidya Aditya S.12ORCID,Helander Jonathan D. M.12ORCID,Peterson Francis C.3ORCID,Elzinga Dezi12,Dejonghe Wim12ORCID,Kaundal Amita14ORCID,Park Sang-Youl12ORCID,Xing Zenan12ORCID,Mega Ryousuke5ORCID,Takeuchi Jun67ORCID,Khanderahoo Bardia12ORCID,Bishay Steven12ORCID,Volkman Brian F.3ORCID,Todoroki Yasushi67ORCID,Okamoto Masanori89ORCID,Cutler Sean R.12ORCID

Affiliation:

1. Institute for Integrative Genome Biology, University of California, Riverside, Riverside, CA 92521, USA.

2. Department of Botany and Plant Sciences, University of California, Riverside, Riverside, CA 92521, USA.

3. Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

4. Department of Plants, Soils and Climate, Utah State University, Logan, UT 84322, USA.

5. Arid Land Research Center, Tottori University, 1390 Hamasaka, Tottori 680-0001, Japan.

6. Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan.

7. Research Institute of Green Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan.

8. Center for Bioscience Research and Education, Utsunomiya University, 350 Mine, Utsunomiya, Tochigi 321-8505, Japan.

9. PRESTO, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.

Abstract

Plant thirst quenched without water Drought causes many billions of dollars of annual losses to farmers worldwide. Central to a plant's water use efficiency are signaling pathways regulated by the hormone abscisic acid and its receptors. Vaidya et al. screened a pool of candidate small molecules and used structure-guided design to optimize the function of an abscisic acid receptor agonist (see the Perspective by Phillips and Sussman). Application of the agonist protected Arabidopsis , wheat, and tomato from underwatering. Science , this issue p. eaaw8848 ; see also p. 416

Funder

National Science Foundation

Japan Society for the Promotion of Science

Japan Science and Technology Agency

Syngenta Crop Protection

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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