Hippocampal ripples down-regulate synapses-Reference-Cited by-同舟云学术

Hippocampal ripples down-regulate synapses

Published:2018-03-30 Issue:6383 Volume:359 Page:1524-1527
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Norimoto Hiroaki¹²^ORCID,Makino Kenichi¹,Gao Mengxuan¹,Shikano Yu¹,Okamoto Kazuki¹^ORCID,Ishikawa Tomoe¹^ORCID,Sasaki Takuya¹^ORCID,Hioki Hiroyuki³⁴^ORCID,Fujisawa Shigeyoshi²^ORCID,Ikegaya Yuji¹⁵^ORCID

Affiliation:

1. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

2. Laboratory for Systems Neurophysiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako City, Saitama, Japan.

3. Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

4. Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, Tokyo, Japan.

5. Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan.

Abstract

Rebalancing mechanisms during sleep Synapses are often strengthened during wake periods and thus need to be homeostatically readjusted during sleep. During slow-wave sleep, synaptic depression is dominant. Sharp wave and ripple events are transient high-frequency field oscillations that occur spontaneously during slow-wave sleep in the brain. Norimoto et al. found that these events induced long-term depression of hippocampal synapses and may thus help to refine recently acquired memories (see the Perspective by Draguhn). Science , this issue p. 1524 ; see also p. 1461

Funder

Human Frontier Science Program

Japan Society for the Promotion of Science

RIKEN

Japan Science Society

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference42 articles.

1. Molecular and electrophysiological evidence for net synaptic potentiation in wake and depression in sleep

2. Human Cortical Excitability Increases with Time Awake