Peptide YY: A Paneth cell antimicrobial peptide that maintains <i>Candida</i> gut commensalism-Reference-Cited by-同舟云学术

Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism

Published:2023-08-04 Issue:6657 Volume:381 Page:502-508
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pierre Joseph F.¹²^ORCID,Peters Brian M.³^ORCID,La Torre Diana¹,Sidebottom Ashley M.¹^ORCID,Tao Yun¹^ORCID,Zhu Xiaorong¹,Cham Candace M.¹^ORCID,Wang Ling¹^ORCID,Kambal Amal¹,Harris Katharine G.¹⁴^ORCID,Silva Julian F.¹^ORCID,Zaborina Olga⁵,Alverdy John C.⁵^ORCID,Herzog Herbert⁶,Witchley Jessica⁷⁸^ORCID,Noble Suzanne M.⁷^ORCID,Leone Vanessa A.¹⁹^ORCID,Chang Eugene B.¹^ORCID

Affiliation:

1. Department of Medicine, University of Chicago, Chicago, IL, USA.

2. Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA.

3. Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN, USA.

4. Department of Biology, Franklin College, Franklin, IN, USA.

5. Department of Surgery, University of Chicago, Chicago, IL, USA.

6. Garvan Institute of Medical Research, Sydney, Australia.

7. Department of Microbiology and Immunology, School of Medicine, University of California San Francisco, San Francisco, CA, USA.

8. Department of Molecular and Cell Biology, Immunology and Molecular Medicine Division, University of California-Berkeley, CA, USA.

9. Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA.

Abstract

The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY 1-36 ), but not endocrine PYY 3-36 , acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae—but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.abq3178

Reference39 articles.

1. Bacterial Community Variation in Human Body Habitats Across Space and Time

2. Gut hormone PYY3-36 physiologically inhibits food intake

3. Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection

4. Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

5. Paneth Cells: Maestros of the Small Intestinal Crypts

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