Genome Analysis Reveals Pili in Group B Streptococcus-Reference-Cited by-同舟云学术

Genome Analysis Reveals Pili in Group B Streptococcus

Published:2005-07 Issue:5731 Volume:309 Page:105-105
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lauer Peter¹²,Rinaudo Cira D.¹²,Soriani Marco¹²,Margarit Immaculada¹²,Maione Domenico¹²,Rosini Roberto¹²,Taddei Anna Rita¹²,Mora Marirosa¹²,Rappuoli Rino¹²,Grandi Guido¹²,Telford John L.¹²

Affiliation:

1. Chiron Srl, Via Fiorentina 1, 53100 Siena, Italy.

2. Centro Interdipartimentale di Microscopia Elettronica, University of Tuscia, Viterbo, Italy.

Abstract

Pili are essential virulence factors in many Gram-negative bacteria; however, they have not been described in most important Gram-positive pathogens. While screening the sequence of multiple genomes of Group B Streptococcus , we identified protective antigens that formed high molecular weight polymers. Immunogold electron microscopy revealed that the structures have a pilus-like form. These large structures have gone unrecognized in decades of studies of Group B Streptococcus .

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference10 articles.

1. Epidemiology of Group B Streptococcal Disease in the United States: Shifting Paradigms

2. Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae

3. Identification of a Universal Group B Streptococcus Vaccine by Multiple Genome Screen

4. The biology of Gram-positive sortase enzymes

5. P. Lauer et al . unpublished data.

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