Cellular Senescence in Aging Primates-Reference-Cited by-同舟云学术

Cellular Senescence in Aging Primates

Published:2006-03-03 Issue:5765 Volume:311 Page:1257-1257
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Herbig Utz¹²,Ferreira Mark¹²,Condel Laura¹²,Carey Dee¹²,Sedivy John M.¹²

Affiliation:

1. Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI 02903, USA.

2. Department of Comparative Medicine, Southwest Foundation for Biomedical Research, San Antonio, TX 78245, USA.

Abstract

The aging of organisms is characterized by a gradual functional decline of all organ systems. Mammalian somatic cells in culture display a limited proliferative life span, at the end of which they undergo an irreversible cell cycle arrest known as replicative senescence. Whether cellular senescence contributes to organismal aging has been controversial. We investigated telomere dysfunction, a recently discovered biomarker of cellular senescence, and found that the number of senescent fibroblasts increases exponentially in the skin of aging baboons, reaching >15% of all cells in very old individuals. In addition, the same cells contain activated ataxia-telangiectasia mutated kinase and heterochromatinized nuclei, confirming their senescent status.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference8 articles.

1. Telomere Shortening Triggers Senescence of Human Cells through a Pathway Involving ATM, p53, and p21CIP1, but Not p16INK4a

2. Telomere shortening in leukocyte subpopulations from baboons

3. Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

4. SA β Gal staining: Biomarker or delusion

5. Oxidative stress shortens telomeres

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