The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin-Reference-Cited by-同舟云学术

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

Published:2010-01-15 Issue:5963 Volume:327 Page:328-331
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Graham Ian A.¹,Besser Katrin¹,Blumer Susan¹,Branigan Caroline A.¹,Czechowski Tomasz¹,Elias Luisa¹,Guterman Inna¹,Harvey David¹,Isaac Peter G.²,Khan Awais M.¹,Larson Tony R.¹,Li Yi¹,Pawson Tanya¹,Penfield Teresa¹,Rae Anne M.¹,Rathbone Deborah A.¹,Reid Sonja¹,Ross Joe¹,Smallwood Margaret F.¹,Segura Vincent¹,Townsend Theresa¹,Vyas Darshna¹,Winzer Thilo¹,Bowles Dianna¹

Affiliation:

1. Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5YW, UK.

2. IDna Genetics Ltd., Norwich Research Park, Norwich NR4 7UH, UK.

Abstract

The Art of Artemisia As the malaria parasite, which is transmitted through mosquito vectors, develops resistance, previously useful control mechanisms are beginning to fail. Combination therapies based on the plant product artemisinin are a promising alternative. Graham et al. (p. 328 ; see the Perspective by

Milhous and Weina

) have now developed a genetic map of the plant Artemisia annua from which artemisinin is derived. The results lay the foundation for improving agricultural productivity of this natural product, which is becoming increasingly important in the fight against malaria.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference16 articles.

1. World Malaria Report 2008 World Health Organisation; http://apps.who.int/malaria/wmr2008/malaria2008.pdf.

2. Artemisinin Resistance inPlasmodium falciparumMalaria

3. “ Saving Lives Buying Time: Economics of Malaria Drugs in an Age of Resistance ” National Academy of Sciences 2004 www.nap.edu/catalog/11017.html. Global Malaria Action Plan Report of the 2008 Artemisinin Conference 8 to 10 October York UK (www.york.ac.uk/org/cnap/artemisiaproject/pdfs/AEconference-report-web.pdf).

4. Localization of Artemisinin and Artemisitene in Foliar Tissues of Glanded and Glandless Biotypes of Artemisia annua L.

5. Identification of Intermediates and Enzymes Involved in the Early Steps of Artemisinin Biosynthesis inArtemisia annua

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