Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5-Reference-Cited by-同舟云学术

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5

Published:2021-06-04 Issue:6546 Volume:372 Page:1085-1091
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sobreira Débora R.¹^ORCID,Joslin Amelia C.¹^ORCID,Zhang Qi¹²^ORCID,Williamson Iain³,Hansen Grace T.¹^ORCID,Farris Kathryn M.¹^ORCID,Sakabe Noboru J.¹^ORCID,Sinnott-Armstrong Nasa⁴⁵^ORCID,Bozek Grazyna¹^ORCID,Jensen-Cody Sharon O.⁶,Flippo Kyle H.⁶^ORCID,Ober Carole¹^ORCID,Bickmore Wendy A.³,Potthoff Matthew⁶^ORCID,Chen Mengjie¹²^ORCID,Claussnitzer Melina⁵⁷^ORCID,Aneas Ivy¹^ORCID,Nóbrega Marcelo A.¹^ORCID

Affiliation:

1. Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.

2. Section of Genetic Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA.

3. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.

4. Department of Genetics, Stanford University, Stanford 94305 CA, USA.

5. Metabolism Program and Cardiovascular Disease Initiative, Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

6. Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

7. Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02131, USA.

Abstract

Obesity genes working together The biological causes of obesity are not well understood. Sobreira et al. examined the chromatin interactions between key genes in a locus known for its associations with obesity in human patients. In addition to directly interrogating the connections between these genes and examining the mechanisms that regulate their activity, the authors used mouse models to study the target genes' effects on both adipose tissue and brain cells that play a role in regulating dietary preferences. Science , abf1008, this issue p. 1085

Funder

National Institutes of Health

Novo Nordisk Fonden

Mauritius Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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